我们疯狂的憨豆先生(罗温•艾金森RowanAtkinson饰)又来了!这次,我们的憨豆先生在英国一间画廊工作。画廊里的一副传世珍品被美国国家博物馆买走了,憨豆先生所在博物馆要派出一名专家运送这副画到美国。阴差阳错之下,这个专家就由憨豆先生担任了。飞过古板的英国,憨豆先生来到了美国。美国国家博物馆的馆长盛情接待了憨豆,在保险库里,憨豆得以独自一人欣赏名作。正当憨豆洋洋得意地近距离观赏名画之时,憨豆一个喷嚏把口水鼻涕都喷在了这副油画上!眼看油画的色彩开始随着自己的口水四处横流,憨豆慌忙之下拿起抹布想把自己的口水擦干。这一下,这副珍品彻底毁了!憨豆最后会否因为毁坏名画而被关进监狱? In 1939, WBN, a fourth radio network, is about to take to America's airwaves. As if the confusion of the premiere night wasn't enough, Penny Henderson, the owner's secretary, must deal with an unhappy sponsor, an overbearing boss and a soon-to-be ex-husband who desperately wants her back. As the broadcast begins, a mysterious voice breaks the broadcast and suddenly members of the cast turn up dead. It's up to her husband Roger, to find out whodunit as the police chase him through the halls of WBN.